| http://purl.uniprot.org/citations/12037567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12037567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12037567 | http://www.w3.org/2000/01/rdf-schema#comment | "Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. A 66-residue domain of Nogo (Nogo-66) is expressed on the surface of oligodendrocytes and can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). The IN-1 monoclonal antibody recognizes Nogo-A and promotes corticospinal tract regeneration and locomotor recovery; however, the undefined nature of the IN-1 epitope in Nogo, the limited specificity of IN-1 for Nogo, and nonspecific anti-myelin effects have prevented a firm conclusion about the role of Nogo-66 or NgR. Here, we identify competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.org/dc/terms/identifier | "doi:10.1038/417547a"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.org/dc/terms/identifier | "doi:10.1038/417547a"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "Strittmatter S.M."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "Strittmatter S.M."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "GrandPre T."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/author | "GrandPre T."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/pages | "547-551"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/pages | "547-551"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/title | "Nogo-66 receptor antagonist peptide promotes axonal regeneration."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/title | "Nogo-66 receptor antagonist peptide promotes axonal regeneration."xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/volume | "417"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://purl.uniprot.org/core/volume | "417"xsd:string |
| http://purl.uniprot.org/citations/12037567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12037567 |
| http://purl.uniprot.org/citations/12037567 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12037567 |
| http://purl.uniprot.org/citations/12037567 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12037567 |
| http://purl.uniprot.org/citations/12037567 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12037567 |