| http://purl.uniprot.org/citations/12039962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12039962 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12039962 | http://www.w3.org/2000/01/rdf-schema#comment | "In the androgen receptor (AR), most of its transactivation activity is mediated via the activation function-1 (AF-1). By employing yeast two-hybrid assay, we isolated a cDNA sequence encoding a protein binding to AR-AF-1. This protein, named ANT-1 (AR N-terminal domain transactivating protein-1), enhanced the ligand-independent autonomous AF-1 transactivation function of AR or glucocorticoid receptor but did not enhance that of estrogen receptor alpha. In contrast, the ANT-1 did not enhance any ligand-dependent AF-2 activities. Furthermore, the ligand-independent interaction between AR-AF-1 and ANT-1 was confirmed in vivo and in vitro. The ANT-1 sequence was identical to that of a protein that binds to U5 small nuclear ribonucleoprotein particle, a human homologue of yeast splicing factor Prp6p, involved in spliceosome. ANT-1 was compartmentalized into 20-40 coarse splicing factor compartment speckles against the background of the diffuse reticular distribution. AR colocalized with ANT-1 only in the diffusely distributed area, whereas the ANT-1 speckles were spatially distinct from but surrounded by the AR compartments. The active gene transcription has been shown to couple simultaneously with pre-mRNA processing at the periphery of the splicing factor compartment. The molecular interaction between two spatially distinct subnuclear compartments mediated by ANT-1 may therefore recruit AR into the transcription-splicing-coupling machinery."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203811200"xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203811200"xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Goto K."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Goto K."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Nomura M."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Nomura M."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Nawata H."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Nawata H."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Okabe T."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Okabe T."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Yanase T."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Yanase T."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Saitoh M."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Saitoh M."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Takayanagi R."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/author | "Takayanagi R."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12039962 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |