| http://purl.uniprot.org/citations/12042308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12042308 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12042308 | http://www.w3.org/2000/01/rdf-schema#comment | "In an attempt to find podocyte-expressed proteins that may interact with the tight junction protein MAGI-1, we screened a glomerulus-enriched cDNA library with a probe consisting of both WW domains of MAGI-1. One of the isolated clones contained two WW domain-binding motifs and was identified as a portion of the actin-bundling protein synaptopodin. In vitro binding assays confirmed this interaction between MAGI-1 and synaptopodin and identified the second WW domain of MAGI-1 to be responsible for the interaction. MAGI-1 and synaptopodin can also interact in vivo, as they can be immunoprecipitated together from HEK293 cell lysates. Another actin-bundling protein that is found in glomerular podocytes and shown to be mutated in an inheritable form of glomerulosclerosis is alpha-actinin-4. We show that alpha-actinin-4 is also capable of binding to MAGI-1 in in vitro binding assays and that this interaction is mediated by the fifth PDZ domain of MAGI-1 binding to the C terminus of alpha-actinin-4. Exogenously expressed synaptopodin and alpha-actinin-4 were found to colocalize along with endogenous MAGI-1 at the tight junction of Madin-Darby canine kidney cells. The interaction and colocalization of MAGI-1 with two actin-bundling proteins suggest that MAGI-1 may play a role in actin cytoskeleton dynamics within polarized epithelial cells."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203072200"xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m203072200"xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Margolis B."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Drescher A.J."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Drescher A.J."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Patrie K.M."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Patrie K.M."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Welihinda A."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/author | "Welihinda A."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/pages | "30183-30190"xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/pages | "30183-30190"xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/title | "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/title | "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1."xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12042308 | http://purl.uniprot.org/core/volume | "277"xsd:string |