| http://purl.uniprot.org/citations/12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12045244 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon (IFN)-gamma-producing CD8+ T cells are important for the successful resolution of the obligate intracellular parasite Toxoplasma gondii by preventing the reactivation or controlling a repeat infection. Previous reports from our laboratory have shown that exogenous interleukin (IL)-15 treatment augments the CD8+ T cell response against the parasite. However, the role of endogenous IL-15 in the proliferation of activated/memory CD8+ T cells during toxoplasma or any other infection is unknown. In this study, we treated T. gondii immune mice with soluble IL-15 receptor alpha (sIL-15Ralpha) to block the host endogenous IL-15. The treatment markedly reduced the ability of the immune animals to control a lethal infection. CD8+ T cell activities in the sIL-15Ralpha-administered mice were severely reduced as determined by IFN-gamma release and target cell lysis assays. The loss of CD8+ T cell immunity due to sIL-15Ralpha treatment was further demonstrated by adoptive transfer experiments. Naive recipients transferred with CD44(hi) activated/memory CD8+ T cells and treated with sIL-15Ralpha failed to resist a lethal T. gondii infection. Moreover, sIL-15Ralpha treatment of the recipients blocked the ability of donor CD44(hi) activated/memory CD8+ T cells to replicate in response to T. gondii challenge. To our knowledge, this is the first demonstration of the important role of host IL-15 in the development of antigen-specific memory CD8+ T cells against an intracellular infection."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20011915"xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Moretto M."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Williams M."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Schwartzman J.D."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Khan I.A."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Liew F.Y."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/author | "Wei X.Q."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/pages | "1463-1470"xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/title | "Treatment with soluble interleukin-15Ralpha exacerbates intracellular parasitic infection by blocking the development of memory CD8+ T cell response."xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://purl.uniprot.org/core/volume | "195"xsd:string |
| http://purl.uniprot.org/citations/12045244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12045244 |
| http://purl.uniprot.org/citations/12045244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12045244 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ6-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q1AHQ7-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q501M1-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_P48346-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q60819-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q80SW0-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q810T6-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q3U1Z6-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |
| http://purl.uniprot.org/uniprot/#_Q9Z0G5-mappedCitation-12045244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12045244 |