http://purl.uniprot.org/citations/12047220 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12047220 | http://www.w3.org/2000/01/rdf-schema#comment | "The Ca(2+)-binding synaptic-vesicle protein synaptotagmin I has attracted considerable interest as a potential Ca(2+) sensor that regulates exocytosis from neurons and neuroendocrine cells. Recent studies have shed new light on the structure, biochemical/biophysical properties and function of synaptotagmin, and the emerging view is that it plays an important role in both exocytosis and endocytosis. At least a dozen additional isoforms exist, some of which are expressed outside of the nervous system, suggesting that synaptotagmins might regulate membrane traffic in a variety of cell types. Here we provide an overview of the members of this gene family, with particular emphasis on the question of whether and how synaptotagmin I functions during the final stages of membrane fusion: does it regulate the Ca(2+)-triggered opening and dilation of fusion pores?"xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20020776"xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/author | "Chapman E.R."xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/author | "Tucker W.C."xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/pages | "1-13"xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/title | "Role of synaptotagmin in Ca2+-triggered exocytosis."xsd:string |
http://purl.uniprot.org/citations/12047220 | http://purl.uniprot.org/core/volume | "366"xsd:string |
http://purl.uniprot.org/citations/12047220 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12047220 |
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http://purl.uniprot.org/uniprot/X2J979 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12047220 |