| http://purl.uniprot.org/citations/12049766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12049766 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch (N) is a large transmembrane protein that acts as a receptor in an evolutionarily conserved intercellular signalling pathway. Because of this conservation, it has been assumed that biochemical events mediating N function are identical in all species. For instance, intracellular maturation by furin protease and subunit assembly leading to the formation of a heterodimeric cell surface N receptor are thought to be central to its function in both mammals and flies. However, in Drosophila the majority of N appears to be full-length. It has not been determined whether this full-length N protein is on the cell surface. We describe experiments which indicate that unlike mammalian N, the majority of Drosophila N on the cell surface is full-length and that in Drosophila, in vivo, furin cleavage is not required for biological activity. We further show that the behaviour of fly and mouse N can be interchanged simply by swapping the regions in which the mammalian furin-like cleavage site is located."xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0925-4773(02)00120-x"xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/author | "Kidd S."xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/author | "Lieber T."xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/name | "Mech Dev"xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/pages | "41-51"xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/title | "Furin cleavage is not a requirement for Drosophila Notch function."xsd:string |
| http://purl.uniprot.org/citations/12049766 | http://purl.uniprot.org/core/volume | "115"xsd:string |
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