| http://purl.uniprot.org/citations/12050147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12050147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12050147 | http://www.w3.org/2000/01/rdf-schema#comment | "The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilated cranial vessels and fail to perfuse the trunk and tail. This phenotype cannot be explained by caudal vessel abnormalities or by a defect in cranial vessel patterning, but instead stems from an increase in endothelial cell number in specific cranial vessels. We show that vbg encodes activin receptor-like kinase 1 (Acvrl1; also known as Alk1), a TGFbeta type I receptor that is expressed predominantly in the endothelium of the vessels that become dilated in vbg mutants. Thus, vbg provides a model for the human autosomal dominant disorder, hereditary hemorrhagic telangiectasia type 2, in which disruption of ACVRL1 causes vessel malformations that may result in hemorrhage or stroke. Movies available on-line"xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.129.12.3009"xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Childs S."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Childs S."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Moon R.T."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Fishman M.C."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Fishman M.C."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lechleider R.J."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lechleider R.J."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Weinstein B.M."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Weinstein B.M."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Kulik M."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Kulik M."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Roman B.L."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Roman B.L."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lawson N.D."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lawson N.D."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Pham V.N."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Pham V.N."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lekven A.C."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Lekven A.C."xsd:string |
| http://purl.uniprot.org/citations/12050147 | http://purl.uniprot.org/core/author | "Garrity D.M."xsd:string |