| http://purl.uniprot.org/citations/12054647 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12054647 | http://www.w3.org/2000/01/rdf-schema#comment | "Programmed cell death 4 (PDCD4) has a common MI domain sharing with death associated protein 5 (DAP5) and a component of eukaryotic translation initiation factor (eIF4G) complex and it might also work as a tumor suppressor. We could find that the message and product of Pdcd4 gene were up-regulated in senescent human diploid fibroblasts. In yeast two hybrid analysis, the C-terminal region of PDCD4 interacted with ribosomal protein S13 (RPS13), ribosomal protein L5 (RPL5), and TI-227H. In in vitro binding assay, RPS13, a component of 40S ribosome was stably bound to PDCD4. We also found that PDCD4 was localized to polysome fractions. We could pull out eIF4G with GST-PDCD4, but eIF4E did not interact with PDCD4. From these results, we could assume that PDCD4 might regulate the eIF4G-dependent translation through direct interactions with eIF4G and RPS13 in senescent fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)00264-4"xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/author | "Lee J.Y."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/author | "Kang M.J."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/author | "Matsuhashi S."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/author | "Ahn H.S."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/author | "Park W.Y."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/pages | "617-621"xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/title | "Up-regulation of PDCD4 in senescent human diploid fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/12054647 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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