| http://purl.uniprot.org/citations/12054677 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12054677 | http://www.w3.org/2000/01/rdf-schema#comment | "In immature and mature primary cultured rat calvarial osteoblasts, both mRNA and corresponding proteins were constitutively expressed for 2 splice variants of GABA(B) receptor (GABA(B)R) subunits but not for any known GABA(A) and GABA(C) receptor subunits. The agonist for GABA(B)R baclofen significantly inhibited cAMP formation induced by forskolin in a manner sensitive to the antagonist 2-hydroxysaclofen. Similar expression was seen with mRNA for GABA(B)R-1a and -1b splice variants in the murine calvarial osteoblast cell line MC3TC-E1 cells cultured for 7-21 days in vitro (DIV). In these MC3T3-E1 cells, baclofen not only inhibited the activity of alkaline phosphatase, but also exacerbated Ca2+ accumulation, throughout the culture period up to 28 DIV. These results suggest that GABA may play an unidentified role in mechanisms associated with cellular proliferation, differentiation, and/or development through functional GABA(B)R constitutively expressed in cultured osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0006-291x(02)00405-9"xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/author | "Yoneda Y."xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/author | "Fujimori S."xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/author | "Hinoi E."xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/pages | "1445-1452"xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/title | "Functional GABA(B) receptors expressed in cultured calvarial osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/12054677 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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