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http://purl.uniprot.org/citations/12055244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12055244http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12055244http://www.w3.org/2000/01/rdf-schema#comment"T cell activation and immune function are regulated by costimulatory molecules of the B7 superfamily. Human B7-H3 is a recent addition to this family and has been shown to mediate T cell proliferation and IFN-gamma production. In this work we describe the identification of the mouse B7-H3 homolog, which is ubiquitously expressed in a variety of tissues. Activated CD4 and CD8 T cells express a putative receptor that can be recognized by soluble mouse B7-H3-Ig molecules. While the mouse B7-H3 gene was found to contain a single copy, we discovered a novel isoform of human B7-H3 (named as B7-H3b hereafter) with four Ig-like domains that results from gene duplication and differential splicing. B7-H3b is the major isoform expressed in several tissues. This structural information suggests a genetic variation of the B7-H3 gene in mammalian species."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.org/dc/terms/identifier"doi:10.4049/jimmunol.168.12.6294"xsd:string
http://purl.uniprot.org/citations/12055244http://purl.org/dc/terms/identifier"doi:10.4049/jimmunol.168.12.6294"xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Richards S."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Richards S."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Sun M."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Sun M."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Dong C."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Dong C."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Mai X.M."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Mai X.M."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Rudensky A."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Rudensky A."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Prasad D.V."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/author"Prasad D.V."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/name"J. Immunol."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/pages"6294-6297"xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/pages"6294-6297"xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/title"Characterization of mouse and human B7-H3 genes."xsd:string
http://purl.uniprot.org/citations/12055244http://purl.uniprot.org/core/title"Characterization of mouse and human B7-H3 genes."xsd:string