| http://purl.uniprot.org/citations/12055627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12055627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12055627 | http://www.w3.org/2000/01/rdf-schema#comment | "Type 1 helper T (T(H)1) cells are essential for cellular immunity, but their ontogeny, maturation and durability remain poorly understood. By constructing a dominant-negative form of T-bet, we were able to determine the role played by this lineage-inducing trans-activator in the establishment and maintenance of heritable T(H)1 gene expression. Optimal induction of interferon-gamma (IFN-gamma) expression required genetic interaction between T-bet and its target, the homeoprotein Hlx. In fully mature T(H)1 cells, reiteration of IFN-gamma expression and stable chromatin remodeling became relatively independent of T-bet activity and coincided with demethylation of DNA. In contrast, some lineage attributes, such as expression of IL-12R beta 2 (interleukin 12 receptor beta 2), required ongoing T-bet activity in mature T(H)1 cells and their progeny. These findings suggest that heritable states of gene expression might be maintained by continued expression of the inducing factor or by a mechanism that confers a stable imprint of the induced state."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni807"xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni807"xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Lee H.W."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Chodosh L.A."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Chodosh L.A."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Mullen A.C."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Mullen A.C."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Hutchins A.S."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Hutchins A.S."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Reiner S.L."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "High F.A."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "High F.A."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Sykes K.J."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/author | "Sykes K.J."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/name | "Nat. Immunol."xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/pages | "652-658"xsd:string |
| http://purl.uniprot.org/citations/12055627 | http://purl.uniprot.org/core/pages | "652-658"xsd:string |