| http://purl.uniprot.org/citations/12055636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12055636 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is a phosphatidylinositol-3-OH-kinase (PI(3)K)-dependent process in macrophages. We identified Myo10 (Myosin-X), an unconventional myosin with pleckstrin homology (PH) domains, as a potential downstream target of PI(3)K. Myo10 was recruited to phagocytic cups in a wortmannin-sensitive manner. Expression of a truncation construct of Myo10 (Myo10 tail) in a macrophage cell line or cytosolic loading of anti-Myo10 antibodies in bovine alveolar macrophages inhibited phagocytosis. In contrast, expression of a Myo10 tail construct containing a point mutation in one of its PH domains failed to inhibit phagocytosis. Expression of Myo10 tail inhibited spreading, but not adhesion, on IgG-coated substrates, consistent with a function for Myo10 in pseudopod extension. We propose that Myo10 provides a molecular link between PI(3)K and pseudopod extension during phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb805"xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Cox D."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Dale B.M."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Greenberg S."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Cheney R.E."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Berg J.S."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Cammer M."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/author | "Chinegwundoh J.O."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/pages | "469-477"xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/title | "Myosin X is a downstream effector of PI(3)K during phagocytosis."xsd:string |
| http://purl.uniprot.org/citations/12055636 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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| http://purl.uniprot.org/citations/12055636 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12055636 |
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