| http://purl.uniprot.org/citations/12062054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12062054 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12062054 | http://www.w3.org/2000/01/rdf-schema#comment | "The single C. elegans member of the retinoblastoma gene family, lin-35 Rb, was originally identified as a synthetic Multivulva (synMuv) gene [1]. These genes form two redundant classes, A and B, that repress ectopic vulval cell fate induction. Recently, we demonstrated that lin-35 Rb also acts as a negative regulator of G(1) progression and likely is the major target of cyd-1 Cyclin D and cdk-4 CDK4/6. Here, we describe G(1) control functions for several other class B synMuv genes. We found that efl-1 E2F negatively regulates cell cycle entry, while dpl-1 DP appeared to act both as a positive and negative regulator. In addition, we identified a negative G(1) regulatory function for lin-9 ALY, as well as lin-15B and lin-36, which encode novel proteins. Inactivation of lin-35 Rb, efl-1, or lin-36 allowed S phase entry in the absence of cyd-1/cdk-4 and increased ectopic cell division when combined with cki-1 Cip/Kip RNAi. These data are consistent with lin-35 Rb, efl-1, and lin-36 acting in a common pathway or complex that negatively regulates G(1) progression. In contrast, lin-15B appeared to act in parallel to lin-35. Our results demonstrate the potential for genetic identification of novel G(1) regulators in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)00844-8"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(02)00844-8"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/author | "Boxem M."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/author | "van den Heuvel S."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/pages | "906-911"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/pages | "906-911"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/title | "C. elegans class B synthetic multivulva genes act in G(1) regulation."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/title | "C. elegans class B synthetic multivulva genes act in G(1) regulation."xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/12062054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12062054 |
| http://purl.uniprot.org/citations/12062054 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12062054 |
| http://purl.uniprot.org/citations/12062054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12062054 |
| http://purl.uniprot.org/citations/12062054 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12062054 |
| http://purl.uniprot.org/uniprot/Q22703 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12062054 |
| http://purl.uniprot.org/uniprot/G5EDT1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/12062054 |