| http://purl.uniprot.org/citations/12062423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12062423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12062423 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptotic protease activating factor-1 (Apaf-1) and cytochrome c are cofactors critical for inducing caspase-9 activation following stress-induced apoptosis. One consequence of caspase-9 activation is nuclear-cytoplasmic barrier disassembly, which is required for nuclear caspase-3 translocation. In the nucleus, caspase-3 triggers proteolysis of the caspase-activated DNA nuclease (CAD) inhibitor, causing CAD induction and subsequent DNA degradation. Here we demonstrate that apoptotic cells show perinuclear cytochrome c aggregation, which may be critical for nuclear redistribution of cytochrome c and Apaf-1. We thus indicate that the nuclear redistribution of these cofactors concurs with the previously reported caspase-9-induced nuclear disassembly, and may represent an early apoptotic hallmark."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)02607-8"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)02607-8"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Gonzalez de Buitrago G."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Gonzalez de Buitrago G."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Martinez-A C."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Martinez-A C."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Ruiz-Vela A."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/author | "Ruiz-Vela A."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/name | "FEBS Lett."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/pages | "133-138"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/pages | "133-138"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/title | "Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/title | "Nuclear Apaf-1 and cytochrome c redistribution following stress-induced apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/volume | "517"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://purl.uniprot.org/core/volume | "517"xsd:string |
| http://purl.uniprot.org/citations/12062423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12062423 |
| http://purl.uniprot.org/citations/12062423 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12062423 |
| http://purl.uniprot.org/citations/12062423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12062423 |
| http://purl.uniprot.org/citations/12062423 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12062423 |