| http://purl.uniprot.org/citations/12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12062898 | http://www.w3.org/2000/01/rdf-schema#comment | "The cytoplasmic carboxyl-terminus of G-protein coupled receptors (GPCRs), absent in the mammalian gonadotropin-releasing hormone receptor (GnRHR), plays an important role in receptor expression, desensitization, internalization and efficiency of coupling to G proteins. Regulators of G protein signaling (RGS) likewise are involved in regulating GPCR-G protein mediated responses and can regulate transcription of other genes. In this study, we evaluate differential expression, ligand binding and effector coupling of the rat GnRHR (rGnRHR) and a chimera of rGnRHR with the pre-mammalian carboxyl domain (rGnRHR-C-tail). Membrane expression of the chimeric receptor and G(q)alpha and G(s)alpha-mediated signaling was increased 2- and 1.5-fold, respectively by RGS10, while RGS3 did not interfere with rGnRHR and rGnRHR-C-tail cell surface expression in spite of negatively regulating GnRH-stimulated G(q)alpha-mediated signaling by both receptors. The rGnRHR and rGnRHR-C-tail showed similar internalization rates in the presence of either RGS protein, indicating that the modification of rGnRHR expression and regulation in the presence of a carboxyl-terminus by RGS10 was not caused by alteration of the internalization rate. The observations in this study implicate the carboxyl domain of the receptor as a site of interaction for RGS10, but not RGS3. This is the first evidence of an altered cell surface expression and regulation of the GnRHR bearing a carboxyl-terminus by RGS proteins."xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0303-7207(02)00082-5"xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/author | "Conn P.M."xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/author | "Castro-Fernandez C."xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/name | "Mol Cell Endocrinol"xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/pages | "149-156"xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/title | "Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus."xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/12062898 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12062898 |
| http://purl.uniprot.org/citations/12062898 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12062898 |
| http://purl.uniprot.org/uniprot/#_A6IA02-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A7A9-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/#_A6JCR6-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/#_A6JCR7-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/#_P49806-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/#_P30969-mappedCitation-12062898 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/P49806 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/P30969 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/A0A8I6A7A9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/A6JCR6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/A6JCR7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |
| http://purl.uniprot.org/uniprot/A6IA02 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12062898 |