| http://purl.uniprot.org/citations/12064941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12064941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12064941 | http://www.w3.org/2000/01/rdf-schema#comment | "Invertebrates and in Drosophila, lamins and lamin-associated proteins are primary targets for cleavage by caspases. Eliminating mammalian lamins causes apoptosis, whereas expressing mutant lamins that cannot be cleaved by caspase-6 delay apoptosis. Caenorhabditis elegans has a single lamin protein, Ce-lamin, and a caspase, CED-3, that is responsible for most if not all somatic apoptosis. In this study we show that in C. elegans embryos induced to undergo apoptosis Ce-lamin is degraded surprisingly late. In such embryos CED-4 translocated to the nuclear envelope but the cytological localization of Ce-lamin remained similar to that in wild-type embryos. TUNEL labeling indicated that Ce-lamin was degraded only after DNA is fragmented. Ce-lamin, Ce-emerin, or Ce-MAN1 were not cleaved by recombinant CED-3, showing that these lamina proteins are not substrates for CED-3 cleavage. These results suggest that lamin cleavage probably is not essential for apoptosis in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.org/dc/terms/identifier | "doi:10.1006/jsbi.2002.4452"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.org/dc/terms/identifier | "doi:10.1006/jsbi.2002.4452"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Gruenbaum Y."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Gruenbaum Y."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Hersh B.M."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Hersh B.M."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Tzur Y.B."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/author | "Tzur Y.B."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/name | "J. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/name | "J. Struct. Biol."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/pages | "146-153"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/pages | "146-153"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/title | "Fate of the nuclear lamina during Caenorhabditis elegans apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/title | "Fate of the nuclear lamina during Caenorhabditis elegans apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://purl.uniprot.org/core/volume | "137"xsd:string |
| http://purl.uniprot.org/citations/12064941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12064941 |
| http://purl.uniprot.org/citations/12064941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12064941 |