| http://purl.uniprot.org/citations/12065839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12065839 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12065839 | http://www.w3.org/2000/01/rdf-schema#comment | "The transmembrane protein LAT (linker for activation of T cells) couples the T cell receptor (TCR) to downstream signaling effectors. Mice homozygous for a mutation of a single LAT tyrosine residue showed impeded T cell development. However, later they accumulated polyclonal helper T (TH) cells that chronically produced type 2 cytokines in large amounts. This exaggerated TH2 differentiation caused tissue eosinophilia and massive maturation of plasma cells secreting to immunoglobulins of the E and G1 isotypes. This paradoxical phenotype establishes an unanticipated inhibitory function for LAT that is critical for the differentiation and homeostasis of TH cells."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1069057"xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1069057"xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Guo X.J."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "He H.T."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "He H.T."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Sainty D."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Sainty D."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Malissen B."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Malissen M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Malissen M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Aguado E."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Aguado E."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Miazek A."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Miazek A."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Richelme M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Richelme M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Mura A.M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Mura A.M."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Nunez-Cruz S."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Nunez-Cruz S."xsd:string |
| http://purl.uniprot.org/citations/12065839 | http://purl.uniprot.org/core/author | "Richelme S."xsd:string |