| http://purl.uniprot.org/citations/12072194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12072194 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of class II major histocompatibility complex (MHC) gene expression is regulated by a master regulator, class II transcriptional activator (CIITA). Transactivation by CIITA requires its nuclear import. This study will address a mechanistic role for the leucine-rich repeats (LRR) of CIITA in regulating nuclear translocation by mutating 12 individual consensus-motif "leucine" residues in both its alpha-motifs and beta-motifs. While some leucine mutations in the LRR motif of CIITA cause congruent loss of transactivation function and nuclear import, other alanine substitutions in both the alpha-helices and the beta-sheets have normal transactivation function but a loss of nuclear accumulation (i.e., functional mutants). This seeming paradox is resolved by the observations that nuclear accumulation of these functional mutants does occur but is significantly less than wild-type. This difference is revealed only in the presence of leptomycin B and actinomycin D, which permit examination of nuclear accumulation unencumbered by nuclear export and new CIITA synthesis. Further analysis of these mutants reveals that at limiting concentrations of CIITA, a dramatic difference in transactivation function between mutants and wild-type CIITA is easily detected, in agreement with their lowered nuclear accumulation. These experiments reveal an interesting aspect of LRR in controlling the amount of nuclear accumulation."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0198-8859(02)00400-7"xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/author | "Harton J.A."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/author | "Linhoff M.W."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/author | "Conti B.J."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/author | "O'Connor W. Jr."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/name | "Hum Immunol"xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/pages | "588-601"xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/title | "Leucine-rich repeats of the class II transactivator control its rate of nuclear accumulation."xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://purl.uniprot.org/core/volume | "63"xsd:string |
| http://purl.uniprot.org/citations/12072194 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12072194 |
| http://purl.uniprot.org/citations/12072194 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12072194 |
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| http://purl.uniprot.org/uniprot/#_A0A087X2I7-mappedCitation-12072194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12072194 |
| http://purl.uniprot.org/uniprot/#_Q71VQ4-mappedCitation-12072194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12072194 |
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| http://purl.uniprot.org/uniprot/#_Q66X48-mappedCitation-12072194 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12072194 |
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