Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12073410http://www.w3.org/2000/01/rdf-schema#comment"

Background

Platelet adhesion and aggregation are mediated by specific platelet membrane glycoproteins GPla/IIa, GPlb alpha, and GPIIb/IIIa, and are essential steps in thrombus formation and development of acute myocardial infarction.

Objective

To evaluate the risks exerted by each of the following polymorphisms in young males with AMI: HPA-1a/b in GPIIIa: 807C/T in GPIa; and HPA-2a/b. VNTR and Kozak C/T in GPlb alpha.

Methods

We conducted a case-control study of 100 young males with first AMI before the age of 53 and 119 healthy controls of similar age. All subjects were tested for the above polymorphisms.

Results

The allele frequencies of each of the platelet polymorphisms were not significantly different between the young man with AMI and the controls. Smoking alone was associated with a 9.97-fold risk, and the presence of at least one metabolic risk factor resulted in a 2.57-fold risk of AMI.

Conclusion

The platelet glycoproteins polymorphisms studied are not an independent risk factor for AMI."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Rosenberg N."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Zivelin A."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Dardik R."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Inbal A."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Chetrit A."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Kornbrot N."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/author"Freimark D."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/name"Isr Med Assoc J"xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/pages"411-414"xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/title"Effects of platelet membrane glycoprotein polymorphisms on the risk of myocardial infarction in young males."xsd:string
http://purl.uniprot.org/citations/12073410http://purl.uniprot.org/core/volume"4"xsd:string
http://purl.uniprot.org/citations/12073410http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12073410
http://purl.uniprot.org/citations/12073410http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/12073410
http://purl.uniprot.org/uniprot/#_A0A193AU54-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A0A193AUC0-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A0A193AUJ5-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A0A193AUV8-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_E0D851-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_E0D852-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A0A0X8AZ85-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A0A5E4DMZ9-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
http://purl.uniprot.org/uniprot/#_A5CKE2-mappedCitation-12073410http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/12073410
▶