| http://purl.uniprot.org/citations/12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12075003 | http://www.w3.org/2000/01/rdf-schema#comment | "In a previous study, we obtained preliminary evidence in a small series of patients (n = 63) suggesting that susceptibility to childhood common acute lymphoblastic leukaemia (c-ALL) was associated with an allele at the HLA-DPB1 locus, DPB1*0201. We have now tested this hypothesis by comparing the frequency of children with leukaemia (n = 982) who typed for specific DPB1 alleles and two groups of non-leukaemic children, one consisting of children with solid tumours, excluding lymphomas (n = 409), the other consisting of normal infants (n = 864). We found that significantly more children with c-ALL and T-ALL, but not pro-B ALL or acute non-ALL typed for DPB1*0201 as compared with children with solid tumours [odds ratio (OR), 95% confidence interval (CI) for c-ALL: 1.76, 1.20-2.56; T-ALL: 1.93, 1.01-3.80] and normal infants (OR, 95% CI for c-ALL: 1.83, 1.34-2.48; T-ALL: 2.00, 1.10-3.82). In childhood c-ALL, significantly more children than those with solid tumours or normal infants typed for DPB1 alleles coding specific polymorphic amino acids lining the antigen-binding site of the DPbeta1*0201 allotypic protein, suggesting that susceptibility to childhood c-ALL may be influenced by DPbeta ABS amino acid polymorphisms shared by DPbeta1*0201 and other DPbeta1 allotypes. These results point to a mechanism of c-ALL susceptibility that involves the presentation of specific antigenic peptides, possibly derived from infectious agents, by DPbeta1*0201-related allotypic proteins, leading to the activation of helper T cells mediating proliferative stress on preleukaemic cells."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/11.14.1585"xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Taylor G.M."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Hussain A."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Greaves M."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Watson P."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Ayres M."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Eden O.B."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Alexander F."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Dearden S."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/author | "Ravetto P."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/name | "Hum Mol Genet"xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/pages | "1585-1597"xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/title | "Genetic susceptibility to childhood common acute lymphoblastic leukaemia is associated with polymorphic peptide-binding pocket profiles in HLA-DPB1*0201."xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/12075003 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12075003 |
| http://purl.uniprot.org/citations/12075003 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C545-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C550-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C554-mappedCitation-12075003 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12075003 |