| http://purl.uniprot.org/citations/12077122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077122 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077122 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell antigen receptor (BCR) is coupled to the mobilization of Ca(2+) by the protein-tyrosine kinase, Syk. Syk, recruited to the clustered BCR, becomes phosphorylated on three tyrosines (Tyr-317, Tyr-342, and Tyr-346) located within the linker region that separates the C-terminal catalytic domain from the N-terminal tandem Src homology 2 domains. Phosphorylation within the linker region can be either activating or inhibitory to Ca(2+) mobilization depending on the sites that are modified. Syk that is not phosphorylated on linker region tyrosines couples the BCR to Ca(2+) mobilization through a phosphoinositide 3-kinase-dependent pathway. The phosphorylation of Tyr-342 and -346 enhances the phosphorylation and activation of phospholipase C-gamma and the early phase of Ca(2+) mobilization via a phosphoinositide 3-kinase-independent pathway. The phosphorylation of Tyr-317 strongly dampens the Ca(2+) signal. In cells that lack the Src family kinase, Lyn, the phosphorylation of the inhibitory Tyr-317 is suppressed leading to elevated production of inositol 1,4,5-trisphosphate and an amplified Ca(2+) signal. This provides a novel mechanism by which Lyn functions as an inhibitor of BCR-stimulated signaling. Thus, Syk and Lyn combine to determine the pathway through which the BCR is coupled to Ca(2+) mobilization as well as the magnitude and duration of the Ca(2+) flux."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201362200"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201362200"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Yankee T.M."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Yankee T.M."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Hong J.J."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Hong J.J."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Harrison M.L."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Harrison M.L."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Geahlen R.L."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/author | "Geahlen R.L."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/pages | "31703-31714"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/pages | "31703-31714"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/title | "Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/title | "Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase."xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://purl.uniprot.org/core/volume | "277"xsd:string |
| http://purl.uniprot.org/citations/12077122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12077122 |
| http://purl.uniprot.org/citations/12077122 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12077122 |