| http://purl.uniprot.org/citations/12077124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077124 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077124 | http://www.w3.org/2000/01/rdf-schema#comment | "One of the major oxysterols in the human circulation is 4 beta-hydroxycholesterol formed from cholesterol by the drug-metabolizing enzyme cytochrome P450 3A4. Deuterium-labeled 4 beta-hydroxycholesterol was injected into two healthy volunteers, and the apparent half-life was found to be 64 and 60 h, respectively. We have determined earlier the half-lives for 7 alpha-, 27-, and 24-hydroxycholesterol to be approximately 0.5, 0.75, and 14 h, respectively. Patients treated with certain antiepileptic drugs have up to 20-fold increased plasma concentrations of 4 beta-hydroxycholesterol. The apparent half-life of deuterium-labeled 4 beta-hydroxycholesterol in such a patient was found to be 52 h, suggesting that the high plasma concentration was because of increased synthesis rather than impaired clearance. 4 beta-Hydroxycholesterol was converted into acidic products at a much slower rate than 7 alpha-hydroxycholesterol in primary human hepatocytes, and 4 beta-hydroxycholesterol was 7 alpha-hydroxylated at a slower rate than cholesterol by recombinant human CYP7A1. CYP7B1 and CYP39A1 had no activity toward 4 beta-hydroxycholesterol. These results suggest that the high plasma concentration of 4 beta-hydroxycholesterol is because of its exceptionally slow elimination, probably in part because of the low rate of 7 alpha-hydroxylation of the steroid. The findings are discussed in relation to a potential role of 4 beta-hydroxycholesterol as a ligand for the nuclear receptor LXR."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201712200"xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m201712200"xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Eggertsen G."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Eggertsen G."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Bjoerkhem I."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Bjoerkhem I."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Andersson U."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Andersson U."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Diczfalusy U."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Diczfalusy U."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Ellis E."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Ellis E."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Bodin K."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Bodin K."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Norlin M."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Norlin M."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Pikuleva I."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Pikuleva I."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Rystedt E."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/author | "Rystedt E."xsd:string |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12077124 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |