| http://purl.uniprot.org/citations/12077213 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077213 | http://www.w3.org/2000/01/rdf-schema#comment | "Using homologous recombination, we generated mice lacking phosphodiesterase-mediated (PDE1B) cyclic nucleotide-hydrolyzing activity. PDE1B(-/-) mice showed exaggerated hyperactivity after acute D-methamphetamine administration. Striatal slices from PDE1B(-/-) mice exhibited increased levels of phospho-Thr34 DARPP-32 and phospho-Ser845 GluR1 after dopamine D1 receptor agonist or forskolin stimulation. PDE1B(-/-) and PDE1B(+/-) mice demonstrated Morris maze spatial-learning deficits. These results indicate that enhancement of cyclic nucleotide signaling by inactivation of PDE1B-mediated cyclic nucleotide hydrolysis plays a significant role in dopaminergic function through the DARPP-32 and related transduction pathways."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.22-12-05188.2002"xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/author | "Greengard P."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/author | "Snyder G.L."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/author | "Repaske D.R."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/author | "Reed T.M."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/author | "Vorhees C.V."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/pages | "5188-5197"xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/title | "Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning."xsd:string |
| http://purl.uniprot.org/citations/12077213 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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