| http://purl.uniprot.org/citations/12077367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077367 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12077367 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel phosphorylation-specific antibody (alphapbeta-catenin) was generated against a peptide corresponding to amino acids 33-45 of human beta-catenin, which contained phosphorylated serines at positions 33 and 37. This antibody is specific to phosphorylated beta-catenin and reacts neither with the non-phosphorylated protein nor with phosphorylated or non-phosphorylated plakoglobin. It weakly interacts with S33Y beta-catenin but not with the S37A mutant. pbeta-catenin is hardly detectable in normal cultured cells and accumulates (up to 55% of total beta-catenin) upon overexpression of the protein or after blocking its degradation by the proteasome. Inhibition of both GSK-3beta and the proteasome resulted in a rapid (t1/2=10 minutes) and reversible reduction in pbeta-catenin levels, suggesting that the protein can undergo dephosphorylation in live cells, at a rate comparable to its phosphorylation by GSK-3beta. pbeta-catenin interacts with LEF-1, but fails to form a ternary complex with DNA, suggesting that it is transcriptionally inactive. Immunofluorescence microscopy indicated that pbeta-catenin accumulates in the nuclei of MDCK and BCAP cells when overexpressed and is transiently associated with adherens junctions shortly after their formation. pbeta-catenin only weakly interacts with co-transfected N-cadherin, although it forms a complex with the ubiquitin ligase component beta-TrCP. SW480 colon cancer cells that express a truncated APC, at position 1338, contain high levels of pbeta-catenin, whereas HT29 cells, expressing APC truncated at position 1555, accumulate non-phosphorylated beta-catenin, suggesting that the 1338-1555 amino acid region of APC is involved in the differential regulation of the dephosphorylation and degradation of pbeta-catenin."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115.13.2771"xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.115.13.2771"xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Geiger B."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Geiger B."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Kam Z."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Kam Z."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Sadot E."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Sadot E."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Ben-Ze'ev A."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Conacci-Sorrell M."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Conacci-Sorrell M."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Lando Z."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Lando Z."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Shnizer D."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Shnizer D."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Zharhary D."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Zharhary D."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Zhurinsky J."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/author | "Zhurinsky J."xsd:string |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12077367 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |