| http://purl.uniprot.org/citations/12079355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12079355 | http://www.w3.org/2000/01/rdf-schema#comment | "The nicotinic acetylcholine (ACh) receptor belongs to a superfamily of synaptic ion channels that open in response to the binding of chemical transmitters. Their mechanism of activation is not known in detail, but a time-resolved electron microscopic study of the muscle-type ACh receptor had suggested that a local disturbance in the ligand-binding region and consequent rotations in the ligand-binding alpha subunits, connecting to the transmembrane portion, are involved. A more precise interpretation of this structural change is given here, based on comparison of the extracellular domain of the ACh receptor with an ACh-binding protein (AChBP) to which a putative agonist is bound. We find that, to a good approximation, there are two alternative extended conformations of the ACh receptor subunits, one characteristic of either alpha subunit before activation, and the other characteristic of all three non-alpha subunits and the protomer of AChBP. Substitution in the three-dimensional maps of alpha by non-alpha subunits mimics the changes seen on activation, suggesting that the structures of the alpha subunits are modified initially by their interactions with neighbouring subunits and switch to the non-alpha form when ACh binds. This structural change, which entails 15-16 degrees rotations of the inner pore-facing parts of the alpha subunits, most likely acts as the trigger that opens the gate in the membrane-spanning pore."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0022-2836(02)00381-9"xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/author | "Fujiyoshi Y."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/author | "Miyazawa A."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/author | "Unwin N."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/pages | "1165-1176"xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/title | "Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits."xsd:string |
| http://purl.uniprot.org/citations/12079355 | http://purl.uniprot.org/core/volume | "319"xsd:string |
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