http://purl.uniprot.org/citations/12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/12080001 | http://www.w3.org/2000/01/rdf-schema#comment | "Kit/stem cell factor (SCF ) has been reported to be involved in survival and proliferation of male differentiating spermatogonial cells. This kinetics study was designed to assess the role of Kit/SCF during spermatogenesis in mice, and the extent of male programmed germ cell death was measured between 8 and 150 days of age. For this purpose, 129/Sv inbred mice in which one Kit allele was inactivated by an nlslacZ sequence insertion (Kit(W-lacZ/+)) were compared with 129/Sv inbred mice with wild-type alleles at the Kit locus. Four different approaches were used: 1) morphometric study to assess spermatogenesis, 2) flow cytometry to study testicular cell ploidy, 3) in situ end labeling to detect apoptosis, and 4) follow-up of reporter gene expression. Spermatogenesis was lower in Kit(W-lacZ/+) heterozygous mice both at the onset of spermatogenesis and during adulthood. Indeed, greater apoptosis occurred at the onset of spermatogenesis. This was followed in the adult by a smaller seminiferous tubule diameter and a lower ratio between type B spermatogonia and type A stem spermatogonia in Kit(W-lacZ/+) mice compared with Kit(+/+) mice. These differences are probably related to the Kit haplodeficiency, which was the only difference between the two genotypes. Germ cell counts and testicular cell ploidy revealed delayed meiosis in Kit(W-lacZ/+) mice. Reporter gene expression confirmed expression of the Kit gene at the spermatogonial stage and also revealed Kit expression during the late pachytene/diplotene transition. These results suggest involvement of Kit/SCF at different stages of spermatogenesis."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.org/dc/terms/identifier | "doi:10.1095/biolreprod67.1.70"xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Panthier J.J."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Bernex F."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Cadoret V."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Royere D."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Guerif F."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Hochereau-de Reviers M.T."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Lansac J."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/author | "Rahal-Perola V."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/name | "Biol Reprod"xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/pages | "70-79"xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/title | "Apoptosis, onset and maintenance of spermatogenesis: evidence for the involvement of Kit in Kit-haplodeficient mice."xsd:string |
http://purl.uniprot.org/citations/12080001 | http://purl.uniprot.org/core/volume | "67"xsd:string |
http://purl.uniprot.org/citations/12080001 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12080001 |
http://purl.uniprot.org/citations/12080001 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12080001 |
http://purl.uniprot.org/uniprot/#_A0A1W2P773-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_A4ZVL1-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_C7ENW2-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_P05532-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_P20826-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_Q64384-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |
http://purl.uniprot.org/uniprot/#_Q78ED8-mappedCitation-12080001 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12080001 |