| http://purl.uniprot.org/citations/12080145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12080145 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12080145 | http://www.w3.org/2000/01/rdf-schema#comment | "Inbred mouse strains exhibit significant differences in their susceptibility to viruses in the genus Flavivirus, which includes human pathogens such as yellow fever, Dengue, and West Nile virus. A single gene, designated Flv, confers this differential susceptibility and was mapped previously to a region of mouse chromosome 5. A positional cloning strategy was used to identify 22 genes from the Flv gene interval including 10 members of the 2'-5'-oligoadenylate synthetase gene family. One 2'-5'-oligoadenylate synthetase gene, Oas1b, was identified as Flv by correlation between genotype and phenotype in nine mouse strains. Susceptible mouse strains produce a protein lacking 30% of the C-terminal sequence as compared with the resistant counterpart because of the presence of a premature stop codon. The Oas1b gene differs from all the other murine Oas genes by a unique four-amino acid deletion in the P-loop located within the conserved RNA binding domain. Expression of the resistant allele of Oas1b in susceptible embryo fibroblasts resulted in partial inhibition of the replication of a flavivirus but not of an alpha togavirus."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.142287799"xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.142287799"xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Zhulin I.B."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Zhulin I.B."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Brinton M.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Brinton M.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Scherbik S.V."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Scherbik S.V."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Stockman B.M."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Stockman B.M."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Perelygin A.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/author | "Perelygin A.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/pages | "9322-9327"xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/pages | "9322-9327"xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/title | "Positional cloning of the murine flavivirus resistance gene."xsd:string |
| http://purl.uniprot.org/citations/12080145 | http://purl.uniprot.org/core/title | "Positional cloning of the murine flavivirus resistance gene."xsd:string |