| http://purl.uniprot.org/citations/12083823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12083823 | http://www.w3.org/2000/01/rdf-schema#comment | "The G protein beta3 (GNB3) subunit and HLA are candidate genes predictive of immune response capacity. We therefore studied the influence of both gene systems on cellular and humoral immunity against hepatitis B virus (HBV) in 79 HBV booster-vaccinated healthy volunteers and an independent group of 77 probands after HBV basic immunization. Following booster vaccination, lymphocyte in vitro proliferation after stimulation with HBV surface antigen was 2.5-fold increased in GNB3 825T (TC + TT) vs CC allele carriers (P = 0.01) and was not influenced by HLA-DRB1 or DQB1 alleles. In addition, anti-HBs antibody titers in both groups were 2-fold increased in TC vs CC and decreased in TT vs CC allele carriers. However, antibody titers after HBV booster immunization were elevated in HLA-DQB1*0301 carriers (P corrected = 0.027). In summary, the GNB3 825T allele appears as a marker particularly predictive of cellular and HLA-DQB1*0301 of humoral immune responses following HBV vaccination."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.org/dc/terms/identifier | "doi:10.1006/viro.2002.1467"xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Siffert W."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Roggendorf M."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Grosse-Wilde H."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Ferencik S."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Barsegian V."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/author | "Lindemann M."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/name | "Virology"xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/pages | "245-252"xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/title | "Role of G protein beta3 subunit C825T and HLA class II polymorphisms in the immune response after HBV vaccination."xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12083823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12083823 |
| http://purl.uniprot.org/citations/12083823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12083823 |
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| http://purl.uniprot.org/uniprot/#_A0A076L4M5-mappedCitation-12083823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12083823 |
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