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http://purl.uniprot.org/citations/12086229http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/12086229http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the association between apolipoprotein E (ApoE) genotype and schizophrenia.

Method

We genotyped 106 schizophrenic out-patients [Diagnostic Statistic Manual IV (DSM-IV) criteria] and 250 healthy volunteers (hospital staff and blood donors) from Asturias (Northern Spain). The ApoE genotypes (epsilon2, epsilon3, epsilon4-alleles) were determined after polymerase chain reaction (PCR) amplification, followed by digestion with the restriction enzyme Cfol and electrophoresis on a 4% agarose gel.

Results

No significant differences in ApoE-allele frequencies between patients and controls was found, although an increased 64-frequency was recorded in patients compared with controls [9.0% vs. 6.2%, P = 0.124; odds ratio (OR) = 1.49; 95% confidence interval (CI) = 0.82-2.70]. ApoE-genotype frequencies did not differ between both groups. The mean age of onset for schizophrenic patients that carried the epsilon4-allele was not significantly different from that of patients without this allele.

Conclusion

Variation in the ApoE gene was not associated with the development of schizophrenia in our population. ApoE-genotypes did not modify the age of onset of the disease."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.org/dc/terms/identifier"doi:10.1034/j.1600-0447.2002.10488.x"xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Fernandez J.M."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Alvarez V."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Coto E."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Morales B."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Bobes J."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Bousono M."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"G-Portilla M.P."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/author"Saiz P.A."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/date"2002"xsd:gYear
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/name"Acta Psychiatr Scand"xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/pages"71-75"xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/title"Apolipoprotein E genotype and schizophrenia: further negative evidence."xsd:string
http://purl.uniprot.org/citations/12086229http://purl.uniprot.org/core/volume"105"xsd:string
http://purl.uniprot.org/citations/12086229http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/12086229
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