| http://purl.uniprot.org/citations/12089450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12089450 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12089450 | http://www.w3.org/2000/01/rdf-schema#comment | "Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and myelin-associated glycoprotein (MAG). The receptor for Nogo (NgR) has been identified as an axonal glycosyl-phosphatidyl-inositol (GPI)-anchored protein, whereas the MAG receptor has remained elusive. Here, we show that MAG binds directly, with high affinity, to NgR. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons are rendered MAG-sensitive by expression of NgR. MAG and Nogo-66 activate NgR independently and serve as redundant NgR ligands that may limit axonal regeneration after CNS injury."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073031"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1073031"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Fournier A."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Fournier A."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Strittmatter S.M."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Strittmatter S.M."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Liu B.P."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "Liu B.P."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "GrandPre T."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/author | "GrandPre T."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/pages | "1190-1193"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/pages | "1190-1193"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/title | "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/title | "Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor."xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12089450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12089450 |
| http://purl.uniprot.org/citations/12089450 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12089450 |