| http://purl.uniprot.org/citations/12089669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12089669 | http://www.w3.org/2000/01/rdf-schema#comment | "Whether the host's immune response genes influence the severity of hepatitis C virus (HCV) liver disease is controversial. Human leukocyte antigen (HLA) class II alleles were analyzed in 233 HCV RNA-positive patients with chronic active hepatitis (197 patients with Knodell index of fibrosis F0-F3 and 36 patients with index of F4). The 2 groups did not differ by sex, duration of infection, mode of contamination, alcohol consumption, or HCV genotype. Patients with cirrhosis were older than those without (56+/-12 vs. 46+/-14 years; P<10-4) and had a lower DRB1*11 allele frequency (5.6% vs. 14.5%; P=.037), whereas DRB1*03 and DQB1*0201 frequencies appeared to be higher (DRB1*03, 18.1% vs. 9.6%; DQB1*0201, 37.5% vs. 23.4%; P=.04, corrected P value is not significant). Mean index of fibrosis was higher in DR3-positive than in DR11-positive patients (2.14 vs. 1.58; P=.05). By multivariate analysis, cirrhosis was associated with male sex and age >50 years. HLA class II alleles may weakly contribute to the severity of HCV liver disease. Of persons infected with HCV, only 15%-20% spontaneously clear the virus, and the rest become chronically infected."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.org/dc/terms/identifier | "doi:10.1086/341086"xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Pol S."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Picon M."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Caillat-Zucman S."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Hue S."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Thibault V."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Charlotte F."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Halfon P."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Renou C."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Rifflet H."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Piette J.C."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/author | "Cacoub P."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/pages | "106-109"xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/title | "Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease."xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://purl.uniprot.org/core/volume | "186"xsd:string |
| http://purl.uniprot.org/citations/12089669 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12089669 |
| http://purl.uniprot.org/citations/12089669 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12089669 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-12089669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12089669 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-12089669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12089669 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-12089669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12089669 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-12089669 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12089669 |