| http://purl.uniprot.org/citations/12091396 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12091396 | http://www.w3.org/2000/01/rdf-schema#comment | "Leukocyte migration from bloodstream to tissue requires rapid, coordinated regulation of integrin-dependent adhesion and de-adhesion. In a previous study we demonstrated that inhibition of protein geranylgeranylation inhibited phorbol ester-stimulated avidity modulation of beta(1) integrin in several leukocyte cell lines. Both RhoA and Rap1 require post-translational modification by geranylgeranylation for full function. In this report we identify Rap1, not RhoA, as a critical geranylgeranylated protein mediating phorbol ester-stimulated beta(1) and beta(2) integrin-dependent adhesion of Jurkat cells. Overexpression of the Rap1-specific GTPase-activating protein, SPA-1, or inactivated form of Rap1 (N17Rap1) blocked phorbol ester-stimulated adhesion of Jurkat cells to fibronectin (alpha(4)beta(1)) and ICAM-1 (alpha(L)beta(2)). With high concentrations of fibronectin as ligand, Jurkat cells adhered spontaneously without phorbol ester stimulation. Unlike the phorbol ester-stimulated adhesion, adhesion induced by high density ligand was not dependent upon Rap1 activation or actin cytoskeleton reorganization. Thus, the "inside-out" adhesion signal induced by phorbol ester and the "outside-in" signal induced by high density ligand involve different pathways."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m206208200"xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Liu L."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Harlan J.M."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Lin N."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Tupper J."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Winn R.K."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/author | "Schwartz B.R."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/pages | "40893-40900"xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/title | "The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion."xsd:string |
| http://purl.uniprot.org/citations/12091396 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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