| http://purl.uniprot.org/citations/12093745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093745 | http://www.w3.org/2000/01/rdf-schema#comment | "The enhancement of the human estrogen receptor alpha (hER alpha, NR3A1) activity by the orphan nuclear receptor COUP-TFI is found to depend on the establishment of a tight hER alpha-COUP-TFI complex. Formation of this complex seems to involve dynamic mechanisms different from those allowing hER alpha homodimerization. Although the hER alpha-COUP-TFI complex is present in all cells tested, the transcriptional cooperation between the two nuclear receptors is restricted to cell lines permissive to hER alpha activation function 1 (AF-1). In these cells, the physical interaction between COUP-TFI and hER alpha increases the affinity of hER alpha for ERK2/p42(MAPK), resulting in an enhanced phosphorylation state of the hER alpha Ser118. hER alpha thus acquires a strengthened AF-1 activity due to its hyperphosphorylation. These data indicate an alternative interaction process between nuclear receptors and demonstrate a novel protein intercommunication pathway that modulates hER alpha AF-1."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf344"xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Gannon F."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Kah O."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Salbert G."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Flouriot G."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Metivier R."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Pakdel F."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Gay F.A."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/author | "Hubner M.R."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/pages | "3443-3453"xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/title | "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK."xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12093745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093745 |
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