| http://purl.uniprot.org/citations/12093753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093753 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093753 | http://www.w3.org/2000/01/rdf-schema#comment | "The THO complex is a multimeric factor containing four polypeptides, Tho2, Hpr1, Mft1 and Thp2. Mutations in any of the genes encoding THO confer impairment of transcription and a transcription-dependent hyper-recombination phenotype, suggesting that THO has a functional role in gene expression. Using an in vivo assay developed to study expression of long and G+C-rich DNA sequences, we have isolated SUB2, a gene involved in mRNA splicing and export, as a multicopy suppressor of the gene expression defect of hpr1 Delta. Further investigation of a putative functional relationship between mRNA metabolism and THO revealed that mRNA export mutants sub2, yra1, mex67 and mtr2 have similar defective transcription and hyper-recombination phenotypes as THO mutants. In addition, THO becomes essential in cells with a defective Mex67 mRNA export er. Finally, we have shown that THO has the ability to associate with RNA and DNA in vitro. These results indicate a functional link between the processes of elongation and metabolism of nascent mRNA mediated by THO and mRNA export proteins, which have important consequences for the maintenance of genome stability."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf335"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf335"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Aguilera A."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Jimeno S."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Jimeno S."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Luna R."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Luna R."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Rondon A.G."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/author | "Rondon A.G."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/pages | "3526-3535"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/pages | "3526-3535"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/title | "The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/title | "The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability."xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12093753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093753 |
| http://purl.uniprot.org/citations/12093753 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093753 |