| http://purl.uniprot.org/citations/12093895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12093895 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of T lymphocytes by specific antigen triggers a 3-to 7-day maturation process. Terminal differentiation begins late after T cell activation and involves expression of effector genes, including the chemokine RANTES and its major transcriptional regulator, RANTES factor of late-activated T lymphocytes-1 (RFLAT-1). In this article we demonstrate that RFLAT-1 expression is translationally regulated through its 5'-UTR and in a cell type-specific manner. Overexpression of the translation initiation factor eIF4E increases RFLAT-1 protein, while inhibition of Mnk1, which phosphorylates eIF4E, reduces RFLAT-1 production, indicating cap-dependent translational regulation. These events are regulated by ERK-1/2 and p38 MAP kinases and allow T cells to rapidly adjust RANTES expression in response to changes in the cellular environment, such as stress and/or growth factors. These findings provide a molecular mechanism for a rheostat effect of increasing or decreasing RANTES expression at sites of inflammation. Memory T cells, already poised to make RANTES, are finely regulated by translational control of the major transcription factor regulating RANTES expression. This is the first example of such a mechanism regulating a chemokine, but it seems likely that this will prove to be a general way for cells to rapidly respond to stress, cytokines, and other proinflammatory factors in their local environment."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci15336"xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Sonenberg N."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Clayberger C."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Pyronnet S."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Song A."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Chou S.Y."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Krensky A.M."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/author | "Nikolcheva T."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/pages | "119-126"xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/title | "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes."xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/12093895 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12093895 |
| http://purl.uniprot.org/citations/12093895 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12093895 |
| http://purl.uniprot.org/uniprot/Q8CBF3#attribution-C19E869601CF5D28F2FFFAE7C73116D5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12093895 |
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| http://purl.uniprot.org/uniprot/#_B2R5J8-mappedCitation-12093895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12093895 |
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| http://purl.uniprot.org/uniprot/#_P13501-mappedCitation-12093895 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12093895 |