| http://purl.uniprot.org/citations/12095141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12095141 | http://www.w3.org/2000/01/rdf-schema#comment | "Multiple organ dysfunction syndrome (MODS) is mediated by complex mechanisms in which interactions between activated leukocytes and endothelial cells play a central role. ICAM-1 (intercellular adhesion molecule-1) mediates firm adhesion and transendothelial migration of activated leukocytes from postcapillary venules into the tissue. The present study evaluated the ICAM-1 expression in various organs after 40 min of intestinal ischemia and 1, 3, 6, 12 h of reperfusion (I/R) in the rat, using a dual monoclonal antibody technique (n = 36). Endothelial barrier permeability, using the vascular leakage of radiolabeled human serum albumin was also assessed (n = 12). Neutrophil sequestration in the lungs was quantitated by myeloperoxidase activity and plasma protease inhibitor levels were measured with electroimmunoassay. Significant regional differences were found in ICAM-1 expression between organs, both constitutively and after I/R-injury. The highest constitutive levels were observed in the liver and lungs, followed by the kidneys. The constitutive ICAM-1 expression in the intestines and in the heart was about 1/20 compared with that found in the liver and lungs. The brain and muscle had levels of about 1/150 of that in the liver and lungs. After intestinal I/R, significant increases (17-45%) were found in the lungs, intestines, brain, heart, and muscle. Albumin leakage index (ALI) in all examined organs and myeloperoxidase activity in the lungs increased after I/R-injury. Serum levels of albumin and most protease inhibitors decreased significantly after I/R challenge. Intestinal I/R results in an increase of systemic ICAM-1 expression with marked organ variability. The upregulation of ICAM-1 could represent a crucial step in the adherence- and migration process of activated leukocytes and potentially in the development of tissue injury."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.org/dc/terms/identifier | "doi:10.1097/00024382-200207000-00016"xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Sun Z."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Andersson R."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Andersson E."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Dib M."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Borjesson A."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Lasson A."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Ohlsson T."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/author | "Olanders K."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/name | "Shock"xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/pages | "86-92"xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/title | "The effect of intestinal ischemia and reperfusion injury on ICAM-1 expression, endothelial barrier function, neutrophil tissue influx, and protease inhibitor levels in rats."xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/12095141 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12095141 |
| http://purl.uniprot.org/citations/12095141 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12095141 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QF25-mappedCitation-12095141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12095141 |
| http://purl.uniprot.org/uniprot/#_Q00238-mappedCitation-12095141 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12095141 |
| http://purl.uniprot.org/uniprot/Q00238 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12095141 |
| http://purl.uniprot.org/uniprot/A0A8L2QF25 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12095141 |