| http://purl.uniprot.org/citations/12095635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12095635 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. To investigate the contribution of basic residues of the A helix of HCII to this activation, we constructed amino acid substitutions (K101Q, R103L, and R106L) by site-directed mutagenesis. K101Q greatly reduced heparin cofactor activity and required a more than 10-fold higher concentration of dermatan sulfate to accelerate thrombin inhibition compared with wild-type recombinant HCII. Thrombin inhibition by R106L was not significantly stimulated by dermatan sulfate. These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(02)02930-7"xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Hayashi N."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Kurimoto M."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Endo S."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Hamada H."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Hayakawa Y."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Hirashima Y."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/author | "Kuwayama N."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/pages | "147-150"xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/title | "Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition."xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://purl.uniprot.org/core/volume | "522"xsd:string |
| http://purl.uniprot.org/citations/12095635 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12095635 |
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