| http://purl.uniprot.org/citations/12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12096337 | http://www.w3.org/2000/01/rdf-schema#comment | "The oncogenic fusion protein p210 Bcr-Abl is causally associated with virtually all cases of chronic myelogenous leukemia. The wild-type Bcr product has several recognizable structural and functional motifs including a domain that contains guanine nucleotide exchange activity for Rho family GTPases (DH/PH domain). Although this domain is retained within p210 Bcr-Abl, it has no known signaling activities in vivo. Here we report that a fragment of Bcr that encodes the isolated DH/PH domain is a potent activator of the NF-kappaB transcription factor. Within the context of full length Bcr, this activity is regulated by proximal flanking sequences that suppress the DH/PH domain encoded guanine nucleotide exchange activity. NF-kappaB activation by Bcr is not mediated by nuclear translocation, but rather by p38 mitogen-activated protein kinase (MAPK)-dependent modification of the RelA/p65 transactivation domain. Although we were able to demonstrate that Bcr can function as an exchange factor for Cdc42 in vivo, NF-kappaB activation appears to occur via a Cdc42-independent mechanism. These studies constitute direct evidence that the Bcr RhoGEF domain can function in vivo, and identify a new signaling activity that may contribute to the transforming potential of p210 Bcr-Abl."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1205678"xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/author | "Cheng L."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/author | "Whitehead I.P."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/author | "Mahon G.M."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/author | "Korus M."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/pages | "4601-4612"xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/title | "p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr."xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12096337 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12096337 |
| http://purl.uniprot.org/citations/12096337 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12096337 |
| http://purl.uniprot.org/uniprot/#_P52735-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_Q07889-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_Q07890-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_Q14155-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
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| http://purl.uniprot.org/uniprot/#_Q15052-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_A1L390-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_A0A2X0SFQ7-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_A9UEZ4-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_A9UEZ5-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |
| http://purl.uniprot.org/uniprot/#_A9UEZ7-mappedCitation-12096337 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12096337 |