| http://purl.uniprot.org/citations/12097641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12097641 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12097641 | http://www.w3.org/2000/01/rdf-schema#comment | "A number of poorly characterized genetic modifiers contribute to the extensive variability of von Willebrand disease, the most prevalent bleeding disorder in humans. We find that a genetic lesion inactivating the murine ST3Gal-IV sialyltransferase causes a bleeding disorder associated with an autosomal dominant reduction in plasma von Willebrand factor (VWF) and an autosomal recessive thrombocytopenia. Although both ST3Gal-IV and ST6Gal-I sialyltransferases mask galactose linkages implicated as asialoglycoprotein receptor ligands, only ST3Gal-IV deficiency promotes asialoglycoprotein clearance mechanisms with a reduction in plasma levels of VWF and platelets. Exposed galactose on VWF was also found in a subpopulation of humans with abnormally low VWF levels. Oligosaccharide branch-specific sialylation by the ST3Gal-IV sialyltransferase is required to sustain the physiologic half-life of murine hemostatic components and may be an important modifier of plasma VWF level in humans."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.142005099"xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.142005099"xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ginsburg D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ginsburg D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Varki A."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Varki A."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Levy G.G."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Levy G.G."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ellies L.G."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ellies L.G."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Marth J.D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Marth J.D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Le D.T."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Le D.T."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ditto D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Ditto D."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Wahrenbrock M."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/author | "Wahrenbrock M."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/12097641 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |