| http://purl.uniprot.org/citations/12098698 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12098698 | http://www.w3.org/2000/01/rdf-schema#comment | "The enzymatic conjugation of arginine to the N-termini of proteins is a part of the ubiquitin-dependent N-end rule pathway of protein degradation. In mammals, three N-terminal residues-aspartate, glutamate, and cysteine-are substrates for arginylation. The mouse ATE1 gene encodes a family of Arg-tRNA-protein transferases (R-transferases) that mediate N-terminal arginylation. We constructed ATE1-lacking mouse strains and found that ATE1-/-embryos die with defects in heart development and in angiogenic remodeling of the early vascular plexus. Through biochemical analyses, we show that N-terminal cysteine, in contrast to N-terminal aspartate and glutamate, is oxidized before its arginylation by R-transferase, suggesting that the arginylation branch of the N-end rule pathway functions as an oxygen sensor."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1069531"xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Du F."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Hu R.G."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Varshavsky A."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Kashina A.S."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Kwon Y.T."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Seo J.W."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "Davydov I.V."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/author | "An J.Y."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/pages | "96-99"xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/title | "An essential role of N-terminal arginylation in cardiovascular development."xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://purl.uniprot.org/core/volume | "297"xsd:string |
| http://purl.uniprot.org/citations/12098698 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12098698 |
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