| http://purl.uniprot.org/citations/12101409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12101409 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently isolated a Krüppel-like zinc-finger transcription factor 5 (KLF5; also known as BTEB2 and IKLF), which is markedly induced in activated vascular smooth-muscle cells and fibroblasts. Here we describe our analysis of the in vivo function of KLF5 using heterozygous KLF5-knockout mice (Klf5(+/-)). In response to external stress, Klf5(+/-) mice showed diminished levels of arterial-wall thickening, angiogenesis, cardiac hypertrophy and interstitial fibrosis. Also, angiotensin II induced expression of KLF5, which in turn activated platelet-derived growth factor-A (PDGF-A) and transforming growth factor-beta (TGF-beta) expression. In addition, we determined that KLF5 interacted with the retinoic-acid receptor (RAR), that synthetic RAR ligands modulated KLF5 transcriptional activity, and that in vivo administration of RAR ligands affected stress responses in the cardiovascular system in a KLF5-dependent manner. KLF5 thus seems to be a key element linking external stress and cardiovascular remodeling."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm738"xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Ishikawa T."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Morita H."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Shindo T."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Miyamoto S."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Kadowaki T."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Kawakami H."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Hirata Y."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Moriyama N."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Kagechika H."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Nagai R."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Tobe K."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Maemura K."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Fukushima Y."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Aizawa K."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Kurabayashi M."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Manabe I."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Sata M."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Nishimatsu H."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Kawai-Kowase K."xsd:string |
| http://purl.uniprot.org/citations/12101409 | http://purl.uniprot.org/core/author | "Komukai M."xsd:string |