| http://purl.uniprot.org/citations/12105188 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12105188 | http://www.w3.org/2000/01/rdf-schema#comment | "We define a novel mechanism by which integrins regulate growth factor expression and the survival of carcinoma cells. Specifically, we demonstrate that the alpha 6 beta 4 integrin enhances vascular endothelial growth factor (VEGF) translation in breast carcinoma cells. The mechanism involves the ability of this integrin to stimulate the phosphorylation and inactivation of 4E-binding protein (4E-BP1), a translational repressor that inhibits the function of eukaryotic translation initiation factor 4E (eIF-4E). The regulation of 4E-BP1 phosphorylation by alpha 6 beta 4 derives from the ability of this integrin to activate the PI-3K-Akt pathway and, consequently, the rapamycin-sensitive kinase mTOR that can phosphorylate 4E-BP1. Importantly, we show that this alpha 6 beta 4-dependent regulation of VEGF translation plays an important role in the survival of metastatic breast carcinoma cells by sustaining a VEGF autocrine signaling pathway that involves activation of PI-3K and Akt. These findings reveal that integrin-mediated activation of PI-3K-Akt is amplified by integrin-stimulated VEGF expression and they provide a mechanism that substantiates the reported role of alpha 6 beta 4 in carcinoma progression."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200112015"xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/author | "Chung J."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/author | "Shaw L.M."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/author | "Lipscomb E.A."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/author | "Mercurio A.M."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/author | "Bachelder R.E."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/pages | "165-174"xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/title | "Integrin (alpha 6 beta 4) regulation of eIF-4E activity and VEGF translation: a survival mechanism for carcinoma cells."xsd:string |
| http://purl.uniprot.org/citations/12105188 | http://purl.uniprot.org/core/volume | "158"xsd:string |
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