| http://purl.uniprot.org/citations/12105416 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12105416 | http://www.w3.org/2000/01/rdf-schema#comment | "beta-Arrestins are important in chemoattractant receptor-induced granule release, a process that may involve Ral-dependent regulation of the actin cytoskeleton. We have identified the Ral GDP dissociation stimulator (Ral-GDS) as a beta-arrestin-binding protein by yeast two-hybrid screening and co-immunoprecipitation from human polymorphonuclear neutrophilic leukocytes (PMNs). Under basal conditions, Ral-GDS is localized to the cytosol and remains inactive in a complex formed with beta-arrestins. In response to formyl-Met-Leu-Phe (fMLP) receptor stimulation, beta-arrestin Ral-GDS protein complexes dissociate and Ral-GDS translocates with beta-arrestin from the cytosol to the plasma membrane, resulting in the Ras-independent activation of the Ral effector pathway required for cytoskeletal rearrangement. The subsequent re-association of beta-arrestin Ral-GDS complexes is associated with the inactivation of Ral signalling. Thus, beta-arrestins regulate multiple steps in the Ral-dependent processes that result in chemoattractant-induced cytoskeletal reorganization."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb821"xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Benovic J.L."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Feldman R.D."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Ferguson S.S."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Babwah A.V."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Bhattacharya M."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Dobransky T."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Verdi J.M."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Anborgh P.H."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Rylett R.J."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/author | "Dale L.B."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/pages | "547-555"xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/title | "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization."xsd:string |
| http://purl.uniprot.org/citations/12105416 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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