| http://purl.uniprot.org/citations/12110179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110179 | http://www.w3.org/2000/01/rdf-schema#comment | "Amplification of large genomic regions associated with complex translocations (complicons) is a basis for tumor progression and drug resistance. We show that pro-B lymphomas in mice deficient for both p53 and nonhomologous end-joining (NHEJ) contain complicons that coamplify c-myc (chromosome 15) and IgH (chromosome 12) sequences. While all carry a translocated (12;15) chromosome, coamplified sequences are located within a separate complicon that often involves a third chromosome. Complicon formation is initiated by recombination of RAG1/2-catalyzed IgH locus double-strand breaks with sequences downstream of c-myc, generating a dicentric (15;12) chromosome as an amplification intermediate. This recombination event employs a microhomology-based end-joining repair pathway, as opposed to classic NHEJ or homologous recombination. These findings suggest a general model for oncogenic complicon formation."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00770-5"xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Gao Y."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Lee C."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Morton C.C."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Zhu C."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Fleming J."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Alt F.W."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Ferguson D.O."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Manis J."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/author | "Mills K.D."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/pages | "811-821"xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/title | "Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations."xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/12110179 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12110179 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J1Y0-mappedCitation-12110179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12110179 |
| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-12110179 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12110179 |