| http://purl.uniprot.org/citations/12110183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110183 | http://www.w3.org/2000/01/rdf-schema#comment | "Double-stranded (ds) RNA induces potent gene silencing, termed RNA interference (RNAi). At an early step in RNAi, an RNaseIII-related enzyme, Dicer (DCR-1), processes long-trigger dsRNA into small interfering RNAs (siRNAs). DCR-1 is also required for processing endogenous regulatory RNAs called miRNAs, but how DCR-1 recognizes its endogenous and foreign substrates is not yet understood. Here we show that the C. elegans RNAi pathway gene, rde-4, encodes a dsRNA binding protein that interacts during RNAi with RNA identical to the trigger dsRNA. RDE-4 protein also interacts in vivo with DCR-1, RDE-1, and a conserved DExH-box helicase. Our findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain foreign dsRNA and to present this dsRNA to DCR-1 for processing."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.org/dc/terms/identifier | "doi:10.1016/S0092-8674(02)00793-6"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(02)00793-6"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Siomi H."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Siomi H."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Mello C.C."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Yigit E."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Yigit E."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Tabara H."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/author | "Tabara H."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/pages | "861-871"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/pages | "861-871"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/title | "The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/title | "The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans."xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://purl.uniprot.org/core/volume | "109"xsd:string |
| http://purl.uniprot.org/citations/12110183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12110183 |
| http://purl.uniprot.org/citations/12110183 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12110183 |