| http://purl.uniprot.org/citations/12110581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110581 | http://www.w3.org/2000/01/rdf-schema#comment | "Known eukaryotic selenocysteine (Sec)-containing proteins are animal proteins, whereas selenoproteins have not been found in yeast and plants. Surprisingly, we detected selenoproteins in a member of the plant kingdom, Chlamydomonas reinhardtii, and directly identified two of them as phospholipid hydroperoxide glutathione peroxidase and selenoprotein W homologs. Moreover, a selenocysteyl-tRNA was isolated that recognized specifically the Sec codon UGA. Subsequent gene cloning and bioinformatics analyses identified eight additional selenoproteins, including methionine-S-sulfoxide reductase, a selenoprotein specific to Chlamydomonas: Chlamydomonas selenoprotein genes contained selenocysteine insertion sequence (SECIS) elements that were similar, but not identical, to those of animals. These SECIS elements could direct selenoprotein synthesis in mammalian cells, indicating a common origin of plant and animal Sec insertion systems. We found that selenium is required for optimal growth of Chlamydomonas: Finally, evolutionary analyses suggested that selenoproteins present in Chlamydomonas and animals evolved early, and were independently lost in land plants, yeast and some animals."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf372"xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf372"xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Gladyshev V.N."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Gladyshev V.N."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Xiang Y."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Novoselov S.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Novoselov S.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Zhi H."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Zhi H."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Kryukov G.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Kryukov G.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Rao M."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Rao M."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Weeks D.P."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Weeks D.P."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Hatfield D.L."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Hatfield D.L."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Onoshko N.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/author | "Onoshko N.V."xsd:string |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110581 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |