| http://purl.uniprot.org/citations/12110588 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12110588 | http://www.w3.org/2000/01/rdf-schema#comment | "The nuclear retinoic acid receptor RAR gamma 2 undergoes proteasome-dependent degradation upon ligand binding. Here we provide evidence that the domains that signal proteasome-mediated degradation overlap with those that activate transcription, i.e. the activation domains AF-1 and AF-2. The AF-1 domain signals RAR gamma 2 degradation through its phosphorylation by p38MAPK in response to RA. The AF-2 domain acts via the recruitment of SUG-1, which belongs to the 19S regulatory subunit of the 26S proteasome. Blocking RAR gamma 2 degradation through inhibition of either the p38MAPK pathway or the 26S proteasome function impairs its RA-induced transactivation activity. Thus, the turnover of RAR gamma 2 is linked to transactivation."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/cdf374"xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/author | "Chambon P."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/author | "Bauer A."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/author | "Garattini E."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/author | "Rochette-Egly C."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/author | "Gianni M."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/pages | "3760-3769"xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/title | "Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation."xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/12110588 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12110588 |
| http://purl.uniprot.org/citations/12110588 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12110588 |
| http://purl.uniprot.org/uniprot/P62195#attribution-283A7BB2A01FCB7CDD88F820DFA51BBA | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12110588 |