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| http://purl.uniprot.org/citations/12110680 | http://www.w3.org/2000/01/rdf-schema#comment | "Early metastatic growth occurs at sites of vascular arrest of blood-borne cancer cells and is entirely intravascular. Here we show that lung colonization by B16-F10 cells is licensed by beta(4) integrin adhesion to the mouse lung endothelial Ca(2+)-activated chloride channel protein mCLCA1. In a manner independent of Met, beta(4) integrin-mCLCA1-ligation leads to complexing with and activation of focal adhesion kinase (FAK) and downstream signaling to extracellular signal-regulated kinase (ERK). FAK/ERK signaling is Src-dependent and is interrupted by adhesion blocking antibodies and by dominant-negative (dn)-FAK mutants. Levels of ERK activation in B16-F10 cells transfected with wild-type or mutant FAK are closely associated with rates of proliferation and bromodeoxyuridine (BrdUrd) incorporation of tumor cells grown in mCLCA1-coated dishes, the ability to form tumor cell colonies on CLCA-expressing endothelial cell monolayers, and the extent of pulmonary metastatic growth. Parallel with the transfection rates, B16-F10 cells transfected with dn-FAK mutants and injected intravenously into syngeneic mice generate approximately half the number and size of lung colonies that vector-transfected B16-F10 cells produce. For the first time, beta(4) integrin ligation to its novel CLCA-adhesion partner is shown to be associated with FAK complexing, activation, and signaling to promote early, intravascular, metastatic growth."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m205307200"xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/author | "Cheng H.C."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/author | "Elble R.C."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/author | "Pauli B.U."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/author | "Abdel-Ghany M."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/pages | "34391-34400"xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/title | "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth."xsd:string |
| http://purl.uniprot.org/citations/12110680 | http://purl.uniprot.org/core/volume | "277"xsd:string |
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