| http://purl.uniprot.org/citations/12111004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/12111004 | http://www.w3.org/2000/01/rdf-schema#comment | "Effects of lead nitrate (LN), a hepatic mitogen, on hepatic gene expressions of lanosterol 14alpha-demethylase (CYP51) and the sterol regulatory element binding proteins (SREBP-1a, SREBP-1c and SREBP-2), which are thought to be transcription factors for hepatic CYP51 gene, were examined by the methods of Northern blot and/or real time reverse transcriptase-polymerase chain reaction (RT-PCR). In both immature (4-week-old) and mature (7-week-old) rats, LN treatment resulted in definite increases in hepatic gene expression of CYP51 at 12 h and in the liver weight at 48 h. As for transcription factors for the CYP51 gene, enhanced gene expression of SREBP-2 was observed 6-12 h after LN treatment, whereas no enhanced gene expression of other SREBPs, SREBP-1a and SREBP-1c, was observed at any time after the treatment; for SREBP-1a, there was no significant change; for SREPB-1c, there was a drastic decrease. In addition, the serum total cholesterol level was increased 12 h after LN treatment to 7-week-old rats, and the increased level was maintained at least up to 48 h later. In the present study, we demonstrate for the first time that LN, a heavy-metal ion, activates the expression of the SREBP-2 and CYP51 genes without decreasing the serum total cholesterol level and further suggest that only SREBP-2 among SREBPs might play an important role in the LN-enhanced CYP51 gene expression."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00204-002-0365-3"xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Kojima M."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Nemoto K."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Ayabe Y."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Yoshimura N."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Degawa M."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/author | "Murai U."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/name | "Arch Toxicol"xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/pages | "398-403"xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/title | "Altered gene expression of hepatic lanosterol 14alpha-demethylase (CYP51) in lead nitrate-treated rats."xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://purl.uniprot.org/core/volume | "76"xsd:string |
| http://purl.uniprot.org/citations/12111004 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/12111004 |
| http://purl.uniprot.org/citations/12111004 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/12111004 |
| http://purl.uniprot.org/uniprot/Q64654#attribution-EE8AC0E8B16FDDED28CC83FB5455B104 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/12111004 |
| http://purl.uniprot.org/uniprot/#_Q64654-mappedCitation-12111004 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/12111004 |
| http://purl.uniprot.org/uniprot/Q64654 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/12111004 |