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| http://purl.uniprot.org/citations/12115603 | http://www.w3.org/2000/01/rdf-schema#comment | "Bcl-xL and Bcl-w specifically interact with PP1alpha and Bad. A phosphatase activity sensitive to okadaic acid was detected in Bcl-xL, Bcl-w and Bad immunoprecipitates. Serine phosphorylation of Bcl-xL and Bcl-w correlates with the number of trimolecular complexes formed. Depletion of Bcl-xL and Bcl-w decreases the remaining Bad-associated phosphatase activity and association of protein phosphatase 1 (PP1)alpha to Bad. Bcl-xL and Bcl-w contain the R/K X V/I X F consensus motif shared by PP1 targeting subunits. This motif, in addition to F X X R X R motif, is involved in binding of Bcl-xL and Bcl-w to PP1alpha. Disruption of Bcl-xL/PP1alpha or Bcl-w/PP1alpha association strongly decreases Bad-associated phosphataseactivity and stability of trimolecular complexes. These results suggest that Bcl-xL and Bcl-w are PP1alpha targeting subunits and this trimolecular complex may be involved in the control of apoptosis."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.org/dc/terms/identifier | "doi:10.1002/1521-4141(200207)32:7<1847::aid-immu1847>3.0.co;2-7"xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/author | "Fleischer A."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/author | "Garcia A."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/author | "Ayllon V."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/author | "Rebollo A."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/author | "Cayla X."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/date | "2002"xsd:gYear |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/pages | "1847-1855"xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/title | "The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad."xsd:string |
| http://purl.uniprot.org/citations/12115603 | http://purl.uniprot.org/core/volume | "32"xsd:string |
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